Postdoctoral Fellow

 
  • EMBL
  • United Kingdom
  • Apr 17, 2021
Science Full Time - Fixed Term

Job Description:

The Petsalaki Group uses data-driven and network-based approaches to understand the principles underpinning context-specific cell signalling. We are an interdisciplinary team using computational and experimental approaches and methods from machine learning and network modelling to CRISPR and phosphoproteomics.

For this project you will be joining a multi-partner exciting collaboration funded by Open Targets to identify combination targets for KRAS-mutant colorectal cancer and triple negative breast cancer. This partnership includes the Garnett Group and industry partners from GSK and Sanofi.  

You will be working in collaboration with the team to analyse the largest genetic interaction dataset generated to date in human cell lines (75K pairs across 50 cell lines) in order to prioritise candidate target pairs for therapeutic applications, understand the mechanisms and principles underpinning these genetic interactions. Additionally you will have the opportunity to develop a predictive model of drug synergy that is also interpretable in terms of mechanism of action. 





Do something meaningful
At EMBL-EBI you can apply your talent and passion to accelerate science and tackle some of humankind's greatest challenges. EMBL-EBI is a worldwide leader in the storage, analysis and dissemination of large biological datasets. We provide the global research community with access to publicly available databases and tools which are crucial for the advancement of healthcare, food security, and biodiversity.  Join a culture of innovation
We are located on the Wellcome Genome Campus, alongside other prominent research and biotech organisations, and surrounded by beautiful Cambridgeshire countryside. This is a highly collaborative and inclusive community where our employees enjoy a relaxed atmosphere. We are committed to ensuring our employees feel valued, supported and empowered to reach their professional potential.  Enjoy lots of benefits: For more details please see our employee benefits page. You can find out more about being a Postdoc at EMBL-EBI here.