Bioinformatician/Senior Bioinformatician - Genetic Data Platform

  • EMBL
  • United Kingdom
  • Apr 2, 2021
Science Full Time - Fixed Term

Job Description:

We are looking to recruit an enthusiastic Bioinformatician to work in the Genetic Data Platform group that is delivering EMBL-EBI’s role in the AMP-T2D Knowledge Portal and the INTERVENE project, addressing human genetic variation data in common diseases and using this data for the calculation of polygenic risk scores.

The AMP-T2D Knowledge Portal aims to make T2D-relevant genetic association data more easily accessible. The portal draws genetic associations and functional genomic data from a federated database with nodes at the Broad Institute Data Coordinating Center (DCC), the European Bioinformatics Institute (EBI), and the University of California San Diego (UCSD). It provides access to these data through application programmatic interfaces (APIs) and a web-portal with visualizations built by the Broad and the University of Michigan (UM). The network of scientists who contribute data or methods to the portal is managed through protocols developed by the DCC. The portal has >20,000 users worldwide and contains data from >80 studies for >180 T2D-relevant traits.

The INTERVENE consortium is a 5-year EU funded project that aims to develop and test next generation tools for disease prevention, diagnosis and personalised treatment utilizing the first US-European pool of genomic and health data and integrating longitudinal and disease-relevant -omics data into genetic risk scores. INTERVENE will build a new European platform that will allow researchers and clinicians to easily calculate genetic scores with the goal to enable a wide adoption of genetic risk scores as a gold standard in clinical research. EMBL-EBI’s role is to deliver this federated platform and to integrate this with controlled access datasets.

The successful applicant will work in a group of Bioinformaticians and Software Developers to deliver EMBL-EBI's contributions to these projects. The team collaborates closely with the NHGRI-EBI GWAS Catalog, the Polygenic Score  Catalog (a collaboration between University of Cambridge and EMBL-EBI), and the Broad Institute. 

The bioinformatician will deliver ingest, harmonisation and analysis of GWAS datasets being on-boarded to the T2DKP at both the EBI and Broad Institute. You will work closely with the GWAS catalog on identifying individual and summary level European based GWAS datasets with phenotypes relevant to T2D for addition to the T2DKP. You will work with the Intervene project’s Data Coordination Centre to ingest, harmonise GWAS from large cohorts to enable analysis, benchmarking by a team of data analysts. Analytical skills are a useful asset.

EMBL-EBI is a worldwide leader in bioinformatics. We encourage personal and professional development and are committed to ensuring our employees feel valued, supported and empowered to reach their potential at work.

Surrounded by beautiful South Cambridgeshire countryside, our state-of-the-art Campus provides employees with a relaxed atmosphere where the pursuit of scientific discovery and meaningful work, underpin every role. In addition, our employees have access to a wide range of benefits including:

This position is project-limited for an initial 3 year duration (or until end 2025). 

To apply please submit a covering letter and CV through our online system.  

At EMBL-EBI, we strongly believe that inclusive and diverse teams benefit from higher levels of innovation and creative thought. We encourage applications from women, LGBTQ and individuals from all nationalities. Visa exemptions will be offered to international candidates and details will be discussed during interview. We believe in science without borders and this continues after Brexit.

This role is based in Hinxton, UK and you will be required to relocate once it is safe to do so if you are currently based abroad or not within commuting distance. More info on how we are recruiting in this period is available on our page: Recruitment and Onboarding during Covid19.

We aim to provide a response within two weeks after the closing date. 

Job no.: EBI01820