Postdoctoral Fellow – Birney Research (MedakaTox)

 
  • EMBL
  • United Kingdom
  • Oct 2, 2020
Science Full Time - Fixed Term

Job Description:

We are looking for an experienced statistical geneticist or genetics aware computational biologist post-doctoral fellow to join the Birney research group at EMBL- EBI to work on a multi-national NIH funded research project to exploring environmental toxicology – MedakaTox.

Over the last seven years dedicated work has led to the establishment of the first near-isogenic panel from a wild fish population in vertebrates, the inbred medaka MIKK panel. This resource provides a unique opportunity for studying the genetic and gene-environment (GxE) effects of environmental contaminant response in a wild-derived vertebrate population.

In this project we will focus on two specific phenotypes, a heart rate and a skeletal assay, testing a range of dosage exposures for 10 or more environmental compounds known to affect the heart, skeleton, or both. For association testing we will use leading genetic techniques, in particular linear mixed models with multi-trait phenotypes, to maximize discovery. High-throughput phenotyping across the MIKK panel will be followed by specific breeding strategy designs and genome sequencing to maximize power for mapping effects to loci.

The project will influence the design and interpretation of human GxE studies, where it is impossible to control exposure, and will provide a comprehensive view of the genetic architecture of the GxE effects.



Experience with knowledge transfer, supervision/mentoring is not required but would be considered as an advantage, as would previous research experience with fish or other aquatic models.

The successful applicant will work as part of a highly collaborative, international team. The fellowship will be based at EMBL-EBI but shared with Woods Hole Oceanographic Institution (Massachusetts, U.S.A). There will be regular project meetings between computational and laboratory members so the ability to explain complex ideas to others is of great importance. The post holder will be required to travel to the US at least once a year and would have the opportunity to spend an extended period at Woods Hole.

EMBL-EBI is a worldwide leader in bioinformatics. As part of the European Molecular Biology Laboratory (EMBL), we are a non-profit, intergovernmental organisation funded by over 27 member states and two associate member states. We encourage personal and professional development and are committed to ensuring our employees feel valued, supported and empowered to reach their potential at work.

Surrounded by picturesque South Cambridgeshire countryside, our Campus provides employees with a relaxed atmosphere where the pursuit of scientific discovery and meaningful work, underpin every role. In addition, our employees have access to a wide range of benefits including:

To apply please submit a covering letter and CV through our online system. At EMBL-EBI, we strongly believe that inclusive and diverse teams benefit from higher levels of innovation and creative thought. We encourage applications from women, LGBTQ and individuals from all nationalities. Applications are encouraged from all nationalities and this has continued after Brexit. For more information please see our website. Visa information will be discussed in more depth with applicants selected for interview.

This position is limited to a 3 year duration in the first instance and is based in Hinxton, UK. More info on how we are recruiting in this period is available on our page: Recruitment and Onboarding during Covid19.

Applications will close at 23:00 GMT on the date listed above.

Appointment will be based on merit alone.